Streamline your Nanoparticle R&D with TAMARA: The Ultimate Plug-and-Play Microfluidics Solution.
TAMARA's user-friendly design supports volumes from microliters to over 10 milliliters, making it ideal for all development stages, from initial screening to in vivo studies. It provides precise control over nanoparticle size, polydispersity index (PDI), and encapsulation efficiency (EE%) for various nanoparticles, including RNA-LNP, liposomes, SLN, and PLGA, even for users with no prior experience.
General
TAMARA is a microfluidic-based nanoparticle formulation system tailored for comprehensive research and development needs. It excels in nanoparticle formulation from initial screening through to in vitro and in vivo testing, managing volumes from 0.2 to 10 mL with exceptional repeatability. This allows consistent use throughout preclinical development without needing to reoptimize formulations.
User-Friendly Design
Developed by microfluidic experts, TAMARA simplifies nanoparticle synthesis. Beginners can synthesize nanoparticles in under two minutes by setting formulation parameters, loading samples, and pressing run. The integrated interface easily manages synthesis conditions, saving and loading runs.
Versatile for All R&D Stages
TAMARA supports all development phases with a single platform, transitioning smoothly from µL-scale screening to in vitro and in vivo testing. Its optimized design maximizes sample usage, even at very low volumes, minimizing losses.
Precision and Repeatability
Equipped with advanced microfluidic mixers, TAMARA offers a broad nanoparticle size range (50–400 nm), a Polydispersity Index (PDI) under 0.2, up to 97% encapsulation efficiency for RNA-LNP, and excellent batch-to-batch consistency (formulation dependant).
Broad Compatibility
TAMARA works with most non-polar solvents and various nanoparticle types, including polymer-based, lipid, and hybrid nanoparticles, making it ideal for encapsulating a wide range of payloads, from RNA and DNA to small drugs and ASOs.
Easy Maintenance & Reusability
Designed for optimal cleanability and reusability, TAMARA minimizes cross-contamination with components like PEEK reservoirs and thermoplastic microfluidic chips, ensuring reliable results with easy cleaning and sterilization.
Note: The guaranteed outcome is for the first run only. Chip's reusability depends on formulation and target volume.
Main features:
- Consistent Results: Ensures batch-to-batch consistency and precise control over nanoparticle characteristics.
- Efficient Reagent Use: Near-zero loss system maximizes reagent usage, reducing waste and optimizing resources.
- Size Control: Easily achieve target nanoparticle sizes through user-friendly interface adjustments.
- Low PDI: Produces homogeneous nanoparticle populations, crucial for efficacy and reduced toxicity.
- High Encapsulation Efficiency: Achieves up to 97% encapsulation efficiency for a variety of payloads.
In summary, TAMARA is a versatile, easy-to-use platform for nanomedicine and LNP R&D, offering unparalleled control, repeatability, and application range, making it a valuable tool for researchers.
Content
1x TAMARA Controller
1x TAMARA Module
1x Reservoir
20x Microfluidic chips
Specifications
General
| Dimensions |
Controller: 31 x 34 x 36 cm / 12.2 x 13.4 x 14.2 in
Synthesis module: 23 x 26 x 23 cm / 9.1 x 10.2 x 9.1 in |
| Weight |
Controller: 4.2 kg / 9.26 lbs
Synthesis module: 3.8 kg / 8.38 lbs |
| User Interface |
Touchscreen (800*480 px) |
Operating Requirements
| Electrical Power |
110-220 V / 36 W |
| Gaz Pressure Input |
8 to 10 bars
Only use dry and non-corrosive nor explosive gas |
| Operating Temperature |
10 – 40°C |
Synthesis Conditions
| Inlet Volumes |
Depend on reservoir size |
| Achievable Volumes |
0.2 - 10 mL |
| Total Flow Rate (TFR) |
0.8 - 15 mL/min |
| Flow Rate Ratio (FRR) Solvent:Water |
1:1 to 1:10 |
| Initial Lipid Concentration Range |
1 to 10 mg/mL |
| Chemical Compatibility |
Any aqueous buffers & polar solvent compatible with the wetted materials (Topas/COC and PEEK – e.g ethanol, methanol, etc.). See Topas and PEEK chemical compatibility here. |
| Material Loss |
< 10% or 50 µL (whichever higher) |
Chip (consumables)
| Material |
COC |
| Designs |
Herringbone and Baffled mixers |
Reservoirs (consumables)
| Material |
PEEK |
| Volume |
0.2 - 3 mL or 1 - 30 mL (both can be combined) |
Typical Expected Outcome
| Nanoparticle Types |
Polymer and lipid-based nanoparticles (PLGA, RNA-LNP, SLN, Liposomes, etc.) |
| Payload* |
All RNA types, DNA, small molecules, peptides |
| Size Range* |
50 – 300 nm |
| Batch to Batch Size Repeatability |
< 3% |
| PDI* |
< 0.2% |
| EE%* |
Up to 97% with RNA-LNP |
*Formulation dependent
Documentation
Tamara - brochure
Tamara - application note: Liposomes synthesis and size characterization with high precision DLS
