The Chamber Interaction Chip - Direct chamber interconnection Fluidic 688 is a microfluidic device with a two-chamber volume for cell culture. Its main purpose is to enable direct interaction between co-cultured cells, simulating organ-organ communication. Volume selection is defined by separate chambers, and it supports two experimental channels, one per chamber. This configuration allows precise control over cell interactions and study of interdependent cellular responses.
General
The chamber interaction chip Fluidic 688 possesses two cell culture chambers, which can be filled individually with different cell types. When used with different organ-specific cell types, the chip provides the possibility to mimic the exchange between these cells (e.g. kindey and liver) and enables to study interdependent cellular responses between organs and demonstrate that such tandem system can greatly improve the reproducibility and efficiency of e.g. toxicity studies. For more information, please refer to Theobald et al. (DOI: 10.1021/acsbiomaterials.7b00417). Please note, if working with adherent cells, we recommend the use of hydrophilized chips as this will help your cells to adhere to the surface of the chip.
Features & Benefits
- Two independent chambers: Allows separate introduction of different cell types to each chamber. This enables controlled co-culture experiments.
- Direct chamber interconnection: Supports real-time cell-to-cell and organ-to-organ interaction, making studies of organ interaction possible.
- Flexible material and surface options: Choose between Topas and PS for compatibility. Hydrophilized options support better cell adherence when needed.
- Mini Luer interface: Ensures easy connection for filling and extraction, minimizing handling error.
- No built-in membrane: Provides direct fluidic communication for more natural cellular interactions.
The Chamber Interaction Chip Fluidic 688 is built for cell culture professionals and researchers interested in co-culture and organ-on-chip applications. Each chip has two fully separated chambers, which can be filled with distinct organ-specific or tissue-specific cell types. When used with different cell types, the device supports direct or mediated exchange between co-cultured populations. This enables more precise and reproducible results in toxicity, transport, or cellular response studies. The chamber design helps to improve the physiological relevance of in vitro experiments.
The device is available in both Topas and PS variants, each with not treated or hydrophilized surface treatment, offering flexibility for various biological and experimental needs. Its simple yet robust architecture, transparent body, and easy-to-use mini Luer interface make it suitable for use in academic and industrial labs. Hydrophilized variants are recommended if you work with adherent cells, as they provide better substrate for cell attachment.
Applications
The Chamber Interaction Chip - Direct chamber interconnection Fluidic 688 is ideal for studying cell interactions in complex biological systems, especially organ-on-chip and co-culture applications. Its design supports:
- Organ-organ communication modeling
- Co-culture assays for toxicity studies
- Cellular transport and metabolic interaction assays
Content
1x Chamber Interaction Chip - Direct chamber interconnection Fluidic 688
Specifications
| SKU | CS-10001055 | CS-10001057 | CS-10001058 |
| Design element | Chamber | Chamber | Chamber |
| Material | Topas | Topas | PS |
| Material chip body | Mcs-COC 13 | Mcs-COC 13 | mcs-PS 17 |
| Material chip lid | mcs-foil 011 (Topas; 140 µm; Tg 78°C) | mcs-foil 011 (Topas; 140 µm; Tg 78°C) | mcs-foil 075 (PS; 125 µm) |
| Color | Transparent | Transparent | Transparent |
| Interface type | Mini Luer interface | Mini Luer interface | Mini Luer interface |
| Surface treatment | Not treated | Hydrophilized | Hydrophilized |
| Membrane | no membrane | no membrane | no membrane |
Documentation
Chamber Interaction Chip - Direct chamber interconnection Fluidic 688 datasheet
Click to read more information about Chamber Interaction Chip - Direct chamber interconnection Fluidic 688 information.
Click to read an application note about the Chamber Interaction Chip - Direct chamber interconnection Fluidic 688.
Check the chemical compatibilities for this product here:
Topas - Chemical Compatibility Chart
Polystyrene - Chemical Compatibility Chart
