These idealized co-culture designs are helpful tools in the organ-on-chip field to mimic cellular interactions in vitro. This design is composed of a central channel surrounded by two outer channels, allowing the modeling of cell-cell interactions or the creation of barriers (Air-Liquid Interface).
General
The IMN2 Linear organ-on-chip design is made of a central channel (tissue chamber) and two outer channels. This side-by-side architecture enables the co-culture of different cell types with real-time visualization. These platforms allow the modeling of physiological shear stress and in vivo-like morphology of tissues.
The separation between the central and outer channels can be done with either slits or pillars and are available in several dimensions. In both cases, slits/pillars are spaced at regular intervals to create a barrier between the inner and outer chambers.
These designs can typically be used in studies modeling lung functions as you can create an air-liquid interface (ALI). They can also be used in a wide range of applications where co-culture or barrier modeling is needed. As an example, you can find those designs in several SynVivo's application kits like SynALI, SynBBB, SynTumor, or SynTox. You can refer to the specific product pages of those applications for more information, examples and protocols.
Content
3x IMN2 Linear chip
Specifications
The chips have the format of a microscopic slide and are made of PDMS bonded to glass.
| |
SY-108011 |
SY-108012 |
SY-108013 |
SY-108007 |
SY-108014 |
| Outer channel (µm) |
200 |
200 |
500 |
200 |
500 |
| Center channel (µm) |
500 |
500 |
500 |
500 |
500 |
| Barrier type |
Slits |
Pillars |
Slits |
Slits |
Pillars |
| Slit spacing S (µm) |
50 |
3 |
50 |
50 |
3 |
| Slit width Ws (µm) |
3 |
20 (diameter) |
3 |
5 |
20 (diameter) |
| Barrier height (µm) |
3 |
3 |
- |
5 |
3 |
| Travel T (µm) |
50 |
50 |
50 |
50 |
50 |
| Depth (µm) |
100 |
100 |
100 |
100 |
100 |
| Examples of applications |
SynBBB, SynTumor, SynALI |
SynTumor |
SynBBB, SynTumor, SynALI, SynTox |
SynTumor |
|
| Chips from starter/assay kits |
Yes |
- |
Yes |
Yes |
- |
